1  The question of whether to use a comma before a terminal subordinate clause is quite complex (ever) since the grammar cops entered the picture.
     2  The question of whether to use a comma before a terminal subordinate clauses is quite complex, since it depends upon so many factors.

This is just one illustration of the statement in 2.  Here, the "since" of time typically does not use a comma, the "since" of reason typically does.  Terminal "though" and "although" clauses are typically set off.
 
Of course, there are editors and there are editors, as I've learned in my 50 year association with the publishing industry.  (Note the comma before the "as.") 

Ed Schuster



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