Seminar of possible interest at the Cinci EPA.

Jim

Subject: Seminar by Dr. Rong-Lin Wang:  Toxicogenomics of endocrine
disrupting chemicals: a transcriptomics-based framework for mechanism
exploration and biomarker discovery


The seminar committee of the Ecological Exposure Research Division
(EERD) of the United States Environmental Protection Agency's National
Exposure Research Laboratory in Cincinnati is pleased to invite you to
attend a seminar by Dr. Rong-Lin Wang, Molecular Ecology Research
Branch, EERD, NERL on February 3, 2011 at AWBERC  in Room 120/126 at
1:00 p.m.

Title: Toxicogenomics of endocrine disrupting chemicals: a
transcriptomics-based framework for mechanism exploration and biomarker
discovery

A small fish computational toxicology project was launched a few years
ago to study the impact of selected endocrine disrupting chemicals
(EDCs) on small fish, using fathead minnow and zebrafish as model
species.  The main goal of this project was to link exposure and effects
of EDCs across multiple levels of the biological hierarchy using
integrated approaches of genomics, proteomics, metabolomics, systems
modeling, and population modeling.  Among the specific objectives of
this three-phased project was to search for mechanistically-based
biomarkers for EDCs.  This talk provides an overview of the phase two
zebrafish transcriptomics work.  A variety of analytical
approaches/computational algorithms were adopted in an attempt to
construct a transcriptomics-based biological framework centered around
the hypothalamic-pituitary-gonadal axis in order to better study the
mechanisms underlying endocrine disruption by these chemicals.  Based on
this framework, efforts were also made to search for candidate,
mechanistically-based molecular indicators for these EDCs.


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